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Wednesday, October 27, 2010

Is Homeopathy a Healing Idea Whose Time Has Come — Again?

Article from Ode Magazine

Valerie Ohanian was a graduate student at the University of Minnesota in the late 1970s when severe fatigue descended out of nowhere. Suddenly, she couldn’t stay up for more than 15 minutes at a time without feeling exhausted. Ohanian consulted several doctors, one of whom suggested she might just be depressed and referred her to a psychologist. The psychologist told her she definitely had health problems.

Nothing Ohanian’s doctors prescribed alleviated her fatigue and painfully swollen glands. She suffered through the mysterious illness for two years, unable to work. “I didn’t know if I’d ever get over it,” she says. “I was really willing to try something different at that point.”

A chiropractor who gave her acupuncture provided some relief, but Ohanian always relapsed in a few days. “The chiropractor told me, ‘I think the only thing that will help you is homeopathy.’ I remembered reading about it and I contacted the only person in Minnesota at that time who was practising,” Ohanian says. “After taking mercurius vivus, the remedy this fellow gave me, I didn’t feel anything for a few days. Then one day I realized I had been up doing things for three hours and I was able to stay up all day. Within a month, I had my energy back.”

She was so moved by her experience that she became a homeopath herself at a time when few were practising in the United States. Twenty-five years later, Ohanian runs a thriving practice in Minneapolis, treating many people like herself for whom conventional medicine has failed to relieve chronic illness, as well as those seeking a deeper sense of well-being.

Ohanian’s story is set against the backdrop of a renaissance in homeopathy, a 200-year-old therapeutic system that aims to stimulate the body to heal itself. Homeopathy is based on the premise of “like cures like” or the law of similars, which posits that a substance that causes symptoms in large doses can cure the same symptoms in small doses. Homeopaths use infinitesimally diluted doses of substances derived from plants, animals and minerals to trigger the body’s natural defense mechanisms. To treat a cold accompanied by a runny nose and watery eyes, for example, a homeopath might prescribe a preparation of allium cepa: in other words, onion.

Advocates emphasize homeopathy’s gentleness—side effects are extremely rare—and holistic methods. Unlike conventional medicine, homeopathy focuses on treating the individual rather than the disease. A homeopath takes a meticulous history of each patient’s physical symptoms, emotional and mental states and overall constitution, seeking the unique aspects that will lead to the precise remedy to promote healing.

This individualized approach is drawing a growing number of people fed up with an expensive, impersonal health-care system that relies on chemical drugs which sometimes end up doing more harm than good. While conventional medicine clearly saves countless lives, particularly in acute illness and emergencies, homeopathy is increasingly a choice among people with chronic health problems, the second most common reason for trips to the doctor’s office in the U.S.

Homeopathy is routinely prescribed for everything from asthma, ear infections and upper respiratory infections, to high blood pressure, sprains and strains and depression. Today it is the most widely used form of alternative medicine in the world, according to the World Health Organization. Approximately 500 million people worldwide receive homeopathic treatment. Homeopathy is most common in India, where there are an estimated 300,000 homeopaths and more than 300 homeopathic hospitals. It also is popular in Europe, South Africa and Brazil. In France, approximately 40 percent of the public has used homeopathic remedies. In the Netherlands, almost half of Dutch physicians consider homeopathic remedies effective, and in Britain, visits to homeopaths are growing by nearly 40 percent a year. In the United States, the number of people using homeopathy increased by an estimated 500 percent during the 1990s.

But last August, the British medical journal The Lancet proclaimed “The End of Homeopathy” in its lead editorial (issue 366), based on a new analysis of earlier studies comparing homeopathy and conventional medicine to the use of placebos. The analysis, conducted by Aijing Shang, Matthias Egger and their colleagues at the University of Berne in Switzerland, on eight placebo-controlled trials with homeopathy and six with conventional medicine, reported that homeopathy appears to work no better than a placebo. In other words, any positive effects from homeopathy are all in people’s heads. Lancet editors concluded, “Now doctors need to be bold and honest with their patients about homeopathy’s lack of benefit, and with themselves for the failings of modern medicine to address patients’ needs for personalized care.”

A number of researchers, however, contend that the editorial is slanted, inaccurate and ignores the real issues. Among them is Dr. Wayne Jonas, who published a meta-analysis incorporating a number of studies, an approach similar to Shang’s in The Lancet in 1997. After analyzing 89 studies, Jonas and his colleagues reported that homeopathy was almost 2 1/2 times more effective than a placebo. Jonas calls the recent editorial “irresponsible” and “a misuse of statistics.” He says statistics are dangerously easy to misconstrue, and in the case of homeopathy, techniques like meta-analysis can fail to accurately capture what’s happening in people’s bodies and lives, which is the real issue that needs investigating.

“I do not agree with the editorial that we should abandon homeopathy,” says Jonas, director of the Samueli Institute of Information Biology in Alexandria, Virginia, and a former director of both the National Institutes of Health’s Office of Alternative Medicine and the World Health Organization (WHO)’s Collaborating Center for Traditional Medicine. “We will never know whether its primary effect is due to a better application of the art of medicine, or if there’s a special effect from the remedies, unless we do research in these areas. Since the public is using homeopathy at a growing rate, then it’s really our obligation as scientists to try to find that out.”
Is homeopathy a 200-year-old hoax, or a powerful paradigm for healing? The pursuit of the truth offers an intriguing glimpse into the tangled—some would say dysfunctional—relationship between the politics of medicine and the advancement of healing. Fasten your seatbelts.

A German physician named Samuel Hahnemann created homeopathy in the late 1700s. Back then, one of the worst places a sick person could wind up was a hospital, where bloodletting and purging were among the cures du jour. Disillusioned after seeing too many patients die from such barbaric practises, the young Dr. Hahnemann decided to switch careers for awhile and translate medical and scientific texts. He was translating William Cullen’s Materia Medica from English to German in 1790 when he encountered Cullen’s idea that Peruvian bark, which we now know contains quinine, cured malaria because it was bitter. The notion made no sense to Hahnemann, but he was intrigued enough that he started experimenting on himself.

After taking several doses of the bark, Hahnemann developed most of the symptoms of malaria. He concluded that the bark was effective because it triggered symptoms similar to those of the disease it treated, and called this effect “the law of similars.” When he gave Peruvian bark to malaria patients to confirm his ideas, they improved.

Hahnemann eventually tested more than 200 medicines of the day—diluting them to reduce toxicity—on himself, his family and a growing group of followers. He meticulously recorded his subjects’ physical, mental and emotional reactions to each substance, establishing the now-standard homeopathic process of “provings” to develop remedies.

As Hahnemann continued this research he also developed his most controversial idea: The more a substance is diluted, the more powerful its healing properties. Homeopathic remedies then, as now, are so diluted they may not contain a single molecule of the original substance. Hahnemann called this process of dilution and shaking “potentization,” which he believed extracted the “spirit-like” nature of each substance that could activate a patient’s “vital force” against disease.

In 1810, Hahnemann laid out his theories and philosophy in his treatise Organon of the Rational Art of Healing. His methods had gained many followers, including European royalty, by the time he coined the term “homeopathy” (for homoios or “similar” and pathos or “suffering”) in 1826.

Homeopathy spread throughout Europe and the U.S. over the next few decades, gaining credibility during epidemics of infectious disease. Patients treated by homeopaths were reported to have had much lower mortality rates than those treated by conventional physicians during cholera epidemics in Europe and the U.S. in the 1830s and ’40s. For example, during a cholera epidemic in Cincinnati, Ohio, in 1849, only three percent of patients who received homeopathic care died, compared with up to 60 percent of patients who received the conventional medical treatment of the time.

But a backlash was brewing on both sides of the Atlantic. Homeopaths were creating serious competition for conventional physicians. Two years after homeopaths organized the American Institute of Homeopathy in 1844, the American Medical Association (AMA) was formed—in part to discredit homeopathy. In 1855, the AMA incorporated a code of ethics that included expulsion of physicians who even consulted with homeopaths or other “non-regular” practitioners. Similar events were unfolding in Europe; orthodox physicians in France also banned consultations with homeopaths. Homeopathy was outlawed in Austria.

In spite of these setbacks, homeopathy continued to flourish, drawing such admirers as Mark Twain, who wrote in Harper’s magazine in 1890, “The introduction of homeopathy forced the old-school doctor to stir around and learn something of a rational nature about his business.” By the turn of the century, more than 100 homeopathic hospitals operated in the U.S., along with 22 homeopathic medical schools and more than 1,000 homeopathic pharmacies. Interestingly, many students and practitioners were women, and the homeopathic Boston Female Medical College, founded as a school for midwives in 1848, was the first women’s medical college in the world.

The early 20th century, however, brought several blows to homeopathy. The Carnegie Foundation issued the Flexner Report in 1910, which, in collaboration with the AMA, sought to standardize medical education. The report rated all medical schools in the U.S and gave nearly all homeopathic colleges—as well as most medical colleges for blacks and women—low scores. Soon, some of these schools started closing, and far fewer graduates of homeopathic colleges were allowed to take medical licensing exams. Soon after, the Rockefeller Foundation boosted conventional medical schools with gifts in the tens of millions.

Conventional medicine became the overwhelmingly dominant paradigm. By 1922, only two homeopathic colleges remained in the U.S. With the exception of India and a few scattered corners of the world, homeopathy went deep underground.

By the time Valerie Ohanian decided to study homeopathy, she couldn’t find a training program in the U.S. She read what she could and eventually found people to teach her. “I had to put things together bit by bit,” she says.

In Europe, however, homeopathy was making a comeback. The person most responsible for that revival is George Vithoulkas, a Greek homeopath who started practising and teaching in the 1960s. Vithoulkas refined Hahnemann’s ideas and brought them into the new frontier of energy medicine. He says homeopathy helps a patient heal by affecting his or her electromagnetic field.

In his seminal book The Science of Homeopathy, Vithoulkas offers a brief but eloquent description of the goal of any healing system. “A human being’s main and final objective is continuous and unconditional happiness,” he wrote. “Any therapeutic system should lead a person toward this goal.” Vithoulkas defined the difference between conventional medicine and homeopathy this way: “Homeopathy does not merely remove disease from the organism; it strengthens and harmonizes the very source of life and creativity in the individual.”

Vithoulkas’ teachings and writings inspired a new generation of homeopaths, including Ohanian, who studied with him in the 1980s. For his groundbreaking work, he received the Right Livelihood Award, or “alternative Nobel Prize” in 1996. In addition to being a powerful teacher, Vithoulkas is also a fearless critic of conventional medicine’s reliance on increasingly harsh and powerful drugs.

Homeopaths believe conventional drugs often suppress symptoms rather than cure illness. Vithoulkas says this suppression actually drives illness deeper into the patient, eventually expressing itself as mental illness and diseases of the central and peripheral nervous system. He also contends that the medical establishment’s overemphasis on increasingly stronger drugs may be making us sicker.

“The immune systems of the Western population, through strong chemical drugs and repeated vaccinations, have broken down,” Vithoulkas told the Swedish Parliament in his acceptance speech for the Right Livelihood Award. He linked the rising rates of diseases such as asthma and cancer with “wrong intervention.” Vithoulkas told the gathering, “If conventional medicine were really curing chronic diseases, today we would have a population in the West that was healthy, mentally, emotionally and physically.”

Although such sweeping statements need to be taken with a grain of salt, they raise provocative questions. Chronic disease is the world’s leading killer, causing approximately 17 million premature deaths worldwide every year, according to WHO. While lifestyle factors like poor diet, smoking and lack of exercise can lead to chronic disease, along with environmental and genetic factors, conventional medicine typically fails to cure people once they’ve gotten sick. Prescription drugs, in fact, sometimes do more harm than good: A 1998 study by researchers at the University of Toronto found that prescription drugs were the fourth leading cause of death in the U.S.

Among the many researchers unconvinced of homeopathy’s “end” is Dr. George Lewith, director of the Complementary Medicine Research Unit at the University of Southampton in England. “People are coming to homeopaths and some are getting better,” Lewith says. “Our patients are telling us that something is going on with complementary medicine and we have to listen and understand that. This is a patient-led revolution, which gets up doctors’ noses a lot.”

Lewith, who has been studying complementary and alternative medicine for years, first prescribed homeopathy to a patient with rheumatoid arthritis 25 years ago. Within two weeks, the woman’s inflammation and arthritis disappeared. “From then on, I thought, ‘This is something very useful,’” Lewith says. “I know you shouldn’t be impressed by such things, but that’s what I found.”

Lewith suspects the consultation process between the patient and the homeopath is a strong influence. He is now investigating this question in a study of rheumatoid arthritis patients in which one group receives a homeopathic remedy and a consultation and the other receives only a remedy. He’s comparing these groups with two others, one receiving a placebo with a consultation and the other receiving only a placebo. “As I’ve gone on over the last 10 years thinking about how we could research homeopathy, it’s increasingly becoming clearer to me that the process of homeopathy and the process of the consultation are probably inseparable,” he says. “I think there’s something quite therapeutic in that process which is different from the almost mechanical consultations that you get in conventional medicine.”

While many like Lewith work on human studies, others are investigating homeopathy’s effects on animals, which offer further insight into the placebo question. Animals don’t make things up; they either get better or they don’t. In an intriguing set of new studies completed last summer, Liesbeth Ellinger, a homeopathic veterinarian in Apeldoorn in the Netherlands, investigated homeopathy’s effect in newborn dairy calves. Diarrhea is a common problem in dairy calves, a condition some Dutch farmers regularly treat with homeopathic remedies. Among Ellinger’s findings: On one farm, not a single calf who received a homeopathic remedy developed diarrhea, while every calf given a placebo did. She says the most difficult part of the research, done with the Louis Bolk Instituut, was persuading farmers to give a placebo instead of homeopathy “because they know homeopathy works.”

In spite of typically limited funding for research, homeopaths around the world are continuing their own investigations and publishing results in homeopathic and alternative medicine journals. They are reporting homeopathy to be particularly promising in treating illnesses and conditions including ADHD (attention deficit/hyperactivity disorder), arthritis, viral illnesses, chronic fatigue syndrome, eczema, inflammatory bowel disease, premenstrual syndrome, and post-traumatic stress, according to the American Institute of Homeopathy. In seminar rooms around the world, homeopaths tell story after story of extraordinary, improbable cures.

Among the believers is Dr. Andrew Weil, director of the Program in Integrative Medicine at the University of Arizona and author of Healthy Aging: A Lifelong Guide to Your Physical and Spiritual Well-Being. “I’ve witnessed homeopathy working in my own life and I’ve seen a great deal of clinical success with it,” he says. “I’d love to know how it works. I think there is some way in which homeopathic remedies convey information to the body and that some day it will be seen as some form of energy medicine, which is up and coming. As that develops, we may have studies that uncover the mechanisms by which homeopathy works.”

Homeopathy defies explanation by conventional science, a valid point that skeptics make over and over again. How can a remedy that might not contain a single molecule of the original substance have any effect at all? If an explanation is ever found, it may be discovered on the frontiers of quantum physics through studies that might yield great material for a sequel to What the Bleep Do We Know?!—the recent movie exploring those sorts of questions.

Wayne Jonas points out that science also has yet to explain the mechanism of action of many conventional drugs. How aspirin works, of all things, has undergone four or five different explanations over the last 100 years. “There are many things we deliver in conventional medicine that we have no idea why they work, or even if they work, but we still allow them and we still continue to research them,” he says.

So much of medicine, like many things that influence our lives, hinges on the “politically dominant standard” of the time, says Dr. Iris Bell, director of research for the Program in Integrative Medicine at the University of Arizona. Bell criticized the editorial in The Lancet, saying tools such as the meta-analysis are “inappropriate to the nature of the intervention that they’re evaluating.” Unlike conventional drugs, which are expected to produce basically the same effect in every person, homeopathic remedies are prescribed for each individual. In other words, three people with the same physical symptoms could easily be given different remedies based upon their unique physical, emotional and mental make-up. In short, evaluating homeopathy is likely impossible using standard methods, and extremely difficult even when using other techniques.

Bell says all medicines—complementary or conventional—should be evaluated for their broader effects on patients’ lives, as well as for safety and cost. One tool to help with such assessments is the well-designed observational study, which measures the effects of an intervention on a patient’s overall well-being, energy level and other “real-life” changes. "If homeopathy and other forms of complementary and alternative medicine were the politically dominant standard, researchers would have every right to evaluate every drug on safety, cost, and whether or not one drug can help improve a broad range of symptoms in the person as a whole—with minimal side-effects—not just an isolated symptom,” she says.

As the debate over homeopathy continues, people are streaming in to see Valerie Ohanian and into the offices of other homeopaths around the world. “I’ve seen our client base go from people at the end who have tried everything else, to people who want to get a constitutional remedy to fine-tune their health,” Ohanian says.

Ohanian is now treating the grandchildren of some of her earliest clients, which she finds particularly gratifying. She talks about a client who had angrily stopped treatment when he was a teenager. Now an adult, he returned recently with his young son. “He told me, ‘I resisted you because my mom made me come. But the peace and light and energy in me went away after I stopped seeing you,’” Ohanian says.

It’s becoming increasingly clear that the medicine of the future needs to focus on strengthening our own healing abilities. After all, that’s our best defense. “We know that the most powerful weapon we have against illness and suffering is our own inherent healing capacities,” Jonas says. “We wouldn’t be around if we weren’t constantly repairing ourselves and becoming more whole.”
The people seeking better health through alternative forms of medicine like homeopathy just want to feel better. They’re not waiting for a paradigm shift in medicine—they’re leading it.
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Some History of the Treatment of Epidemics with Homeopathy

By Julian Winston

From its earliest days, homeopathy has been able to treat epidemic diseases with a substantial rate of success, when compared to conventional treatments. It was these successes that placed the practice of homeopathy so firmly in the consciousness of people world-wide.

There is a story told about Joseph Pulte, one of the earliest homeopaths in Cincinnati. When he began his practice, many people were so angered by a homeopath being in town that they pelted the house with eggs. He was becoming discouraged enough to think of leaving. His wife said, "Joseph, do you believe in the truth of homeopathy?" He replied in the affirmative. "Then," she said, "you will stay in Cincinnati."

Shortly after, when the Cholera epidemic swept through, Pulte was able to boast of not having lost a single patient-- and he was accepted into the community. In the Epidemic of 1849, people crowded to his door and stood in the street because the waiting room was full.

In 1900, Thomas Lindsley Bradford, MD, wrote a book called "The Logic of Figures" in which he collected the statistics he could find that would compare the conventional therapeutics with homeopathic ones. Many of the figures cited below are derived from Bradford's work.

One of the earliest tests of the homeopathic system was in the treatment of Typhus Fever (spread by lice) in an 1813 epidemic which followed the devastation of Napoleon's army marching through Germany to attack Russia, followed by their retreat. When the epidemic came through Leipzig as the army pulled back from the east, Samuel Hahnemann, the founder of homeopathy, was able to treat 180 cases of Typhus-- losing but two. This, at a time when the conventional treatments were having a mortality rate of over 30%.

In 1830 as the cholera epidemic was reported coming from the east, Hahnemann was able to identify the stages of the illness, and predict what remedies would be needed for which stages.

When Cholera finally struck Europe in 1831 the mortality rate (under conventional treatment) was between 40% (Imperial Council of Russia) to 80% (Osler's Practice of Medicine). Out of five people who contracted Cholera, two to four of them died under regular treatment. Dr. Quin, in London, reported the mortality in the ten homeopathic hospitals in 1831-32 as 9%; Dr. Roth, physician to the king of Bavaria, reported that under homeopathic care the mortality was 7%; Admiral Mordoinow of the Imperial Russian Council reported 10% mortality under homeopathy; and Dr. Wild, Allopathic editor of Dublin Quarterly Journal, reported in Austria, the Allopathic mortality was 66% and the homeopathic mortality was 33% "and on account of this extraordinary result, the law interdicting the practice of Homeopathy in Austria was repealed".

Homeopathy continued to be effective in the treatment of Epidemic Cholera. In 1854 a Cholera Epidemic struck London. This was a historically important epidemic in that it was the first time the medical community was able to trace the outbreak to a source (a public water pump), and when the pump was closed, the epidemic soon ceased. The House of Commons asked for a report about the various methods of treating the epidemic. When the report was issued, the homeopathic figures were not included. The House of Lords asked for an explanation, and it was admitted that if the homeopathic figures were to be included in the report, it would "skew the results". The suppressed report revealed that under allopathic care the mortality was 59.2% while under homeopathic care the mortality was only 9%.

It is hard today to comprehend what kind of scourge such an epidemic was. As was seen in the later Flu Epidemic of 1918, one could be healthy in the morning and be dead by evening-- it moved that rapidly. Many books were written about the Homeopathic treatment of Cholera during these times, among them: Cholera and its Homeopathic treatment, F. Humphreys (1849); Homeopathic Treatment of Cholera, B.F. Joslin (1854); Homeopathic Domestic Treatment of Cholera, Biegler (1858); Epidemic Cholera, B. F. Joslin (1885); Asiatic Cholera, Jabez Dake (1886).

The success of homeopathic treatment continued with the later cholera epidemics. In the Hamburg epidemic of 1892, allopathic mortality was 42%, homeopathic mortality was 15.5% During the 1850s, there were several epidemics of Yellow Fever in the southern states. This disease was eventually found to be transmitted by mosquito. Osler says that the allopathic mortality from Yellow Fever is between 15-85%. Holcome, a homeopath, reported in 1853 a mortality of 6.43% in Natchez, and Dr. Davis, another homeopath in Natchez, reported 5.73%. In 1878 the mortality in New Orleans was 50% under allopathic care, and 5.6% (in 1,945 cases in the same epidemic) with homeopathic care.

The two best books on this topic were: Yellow Fever and its Homeopathic Treatment, Holcome, (1856) and The Efficacy of Crotalus Horridus in Yellow Fever, C. Neidhard, (1860).

Another epidemic disease which was treatable with homeopathy was Diphtheria. Since the advent of widespread vaccination, it is a disease not often seen in our modern world. Diphtheria appeared periodically, and rarely had the same presentation. It was, therefore, very important for the practitioner to individualize the treatment in each specific case or generalized epidemic. A remedy which had been effective in treating it one year might not be the same remedy needed the next year.

In the records of three years of Diphtheria in Broome County, NY from 1862 to 1864, there was a report of an 83.6% mortality rate among the allopaths and a 16.4% mortality rate among the Homeopaths. (Bradford)

Perhaps the most recent use of homeopathy in a major epidemic was during the Influenza Pandemic of 1918. The Journal of the American Institute for Homeopathy, May, 1921, had a long article about the use of homeopathy in the flu epidemic. Dr. T A McCann, from Dayton, Ohio, reported that 24,000 cases of flu treated allopathically had a mortality
rate of 28.2% while 26,000 cases of flu treated homeopathically had a mortality rate of 1.05%. This last figure was supported by Dean W.A. Pearson of Philadelphia (Hahnemann College) who collected 26,795 cases of flu treated with homeopathy with the above result.

The most common remedy used was Gelsemium, with occasional cases needing Bryonia and Eupatorium reported. Dr. Herbert A. Roberts from Derby, CT, said that 30 physicians in Connecticut responded to his request for data. They reported 6,602 cases with 55 deaths, which is less than 1%. Dr. Roberts was working as a physician on a troop ship during WWI. He had 81 cases of flu on the way over to Europe. He reported, "All recovered and were landed. Every man received homeopathic treatment. One ship lost 31 on the way."

Closer to our present time, there were the Polio epidemics in the mid-1950s. Dr. Alonzo Shadman, a homeopath in the Boston area, emphasized that until *actual paralysis* was observed, it was hard to distinguish the prodromal symptoms of Polio from those of the common cold-- and he treated many "summer colds" during the time. Were they incipient polio? No one can tell.

Dr. Francisco Eizayaga or Argentina, tells of a polio epidemic in Buenos Aires in 1957, where the symptoms of the epidemic resembled those of the remedy Lathyrus sativa. The homeopathic doctors and pharmacies prescribed Lathyrus 30c as a prophylactic, and "thousands of doses" were distributed. "Nobody registered a case of contagion." Eizayaga points out that in other epidemics of polio, Gelsemium was the indicated remedy-- emphasizing, again, the need for individualization.

Homeopathy has been very effective in treating many of the epidemics during the 19th and early 20th centuries. Why the successes are not better known is a subject for conjecture. It could be that, like the physician quoted below, most would rather not see the ineffectiveness of the conventional therapeutics nor accept the efficacy of homeopathy. From "Homeopathy In Influenza-A Chorus Of Fifty In Harmony" by W. A. Dewey, MD (Journal of the American Institute of Homeopathy, May 1921):

One physician in a Pittsburgh hospital asked a nurse if she knew anything better than what he was doing, because he was losing many cases. "Yes, Doctor, stop aspirin and go down to a homeopathic pharmacy, and get homeopathic remedies". The Doctor replied: "But that is homeopathy." "I know it, but the homeopathic doctors for whom I have nursed have not lost a single case."--W. F. Edmundson, MD, Pittsburgh.
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How Does Homeopathy Work?

By Paul Callinan MSc, ND, DHom, PhD
Recently homoeopathic medicine has risen to new heights of controversy in the world of medical science. Nature, a prestigious journal in the field of Bioscience, has taken the unprecedented step of issuing a warning to readers to suspend judgment on one of its printed research papers. The author and principal experimenter, Professor Jacques Benveniste of the French Medical Research Council, has been subjected to scorn, ridicule, and critical investigation of his experimental procedures because the results he printed supported homoeopathic medicine. Paul Callinan, one of Australia's few homoeopathic researchers, looks at the past and present of this contentious medicine.

The rising profile of homoeopathy has produced something of a dilemma in the world of medicine: does it work or doesn't it? The decision bites deep: if homoeopathic medicine is nothing but fraud, quackery, and placebo, as many of its opponents would maintain, then a large number of competently trained homoeopaths and doctors, together with countless thousands of dedicated lay practitioners have been led up the medical garden path. Their millions of patients, including many heads of state and prominent members of several of Europe's royal families, have fallen victim to the most successful medical hoax ever perpetrated. On the other hand, if homoeopathic medicine is effective, then for the first time in more than a hundred years the Western world is on the verge of developing an entirely new system of medicine. The medicines are non-toxic and easily manufactured; they are also very cheap.

During the 170 years of its existence, homoeopathy has been the centre of continual and often bitter medical controversy. It has been particularly opposed by orthodox medicine, otherwise known as allopathy. But recently, both research and patient support has grown at a rapid pace. Yet rather than being hailed as a possible new medical breakthrough to give better health for all, it has been ridiculed, ignored and systematically suppressed.

Clearly, something is wrong. The problem is that homoeopathic medicines can be diluted to such extremes that it can be shown physically, chemically, and mathematically that there is nothing in the final dose but water. Obviously then, the objection goes, any medicinal effect is nothing but placebo, and the homoeopaths are both frauds and charlatans.

Yet the origins of homoeopathic medicine are both honorable and orthodox. It was developed in Germany by the research of Dr. Samuel Hahnemann (1755-1834), who as well as being an experienced orthodox physician was also a competent chemist, a good mineralogist and botanist, and an able translator of eight different languages. His research stemmed from dissatisfaction with the standard medical practices of his time: routine bleedings, heroic purgings with cathartics, and administration of large doses of crude drugs. While translating Cullen's Materia Medica into German, he was struck by a hitherto unexplored medical observation, first mentioned by Hippocrates. Cullen had proposed that the notable success of cinchona (an extract of quinine bark) in the treatment of swamp fever was due to its value as a stomach tonic. Hahnemann disagreed, and in his research on the question decided to take a course of the cinchona extract himself. To his surprise, he developed a set of symptoms remarkably similar to those of the swamp fever it was used to treat. All the symptoms disappeared when he stopped taking it. Further administration to himself and his family always produced the same symptoms, varying only in degree.

This was a strange phenomenon, uncited in the medical literature of the day. A remedy which was effective in a particular disease would produce a similar set of symptoms in a healthy person, when given in sufficient doses. In searching for precedents for this effect, he established that the first mention made of it was in the writings of Hippocrates (460-377 B.C.), regarded by the orthodoxy as the father of modern medicine. Hippocrates had said that likes can be cured by likes: that vomiting may be stopped by being made to vomit, and any illness caused by one means can be treated successfully by a similar means.

The Law of Similars

From this Hahnemann produced the first axiom of homoeopathy: Similia Similibus Curentur - Let Likes be Cured by Likes, otherwise known as the Law of Similars - and so began his life's work. By 1821 he had produced two major works: The Organon of Rational Medicine, embodying the principles of the homoeopathic approach to medicine, and his Materia Medica Pura, covering the effects of sixty four medicines.

This approach to medicine represents a dramatic move away from the established method. The allopathic approach was of establishing the existence of a particular disease, clarifying its symptoms, and then testing the effectiveness of various medicines on it, by the use of opposites. An illness accompanied by fever and diarrhea, for example, would call for the combined use of medicines which would be anti-febrile and others which would normally constipate, and so in a crude way, a total balance would be found by using a number of appropriate medicines together. The homoeopaths tried the opposite approach: first test a substance for medicinal use, they said, by giving it to healthy volunteers, and carefully noting the symptoms it produces. This is known as a proving. Once the symptom picture has been fully developed over a number of human trials, then it can be assessed for usefulness against diseases with a similar set of symptoms. A substance which produces a bizarre set of symptoms such as bright red orifices and blue-green discharges, for example, will have little use in homoeopathic clinical practice because symptoms of this type are rarely met. However a substance which produces a runny nose, watery red eyes and repeated sneezing would be of great value in the treatment of hay fever. The common onion produces just those symptoms (as countless cooks can guarantee), and by use of the above trial system the onion has now achieved an established place in homoeopathic therapeutics. In essence, allopathic medicine embodies the law of opposites, homoeopathic medicine the law of similars.

Potentisation

At first the homoeopathic approach to medicine seems contradictory. Surely experience would tell us that exposing hay fever sufferers to large doses of onion would just add insult to injury, and make them worse rather than better. The homoeopaths would agree, but with two provisos.

First the symptoms must match closely before onion will have a therapeutic effect; this is embodied in their Law of the Single Remedy, which states that the most effective result will come from the most similar remedy given in single doses. Then after the initial aggravation of symptoms dies down, the hay fever will be noticeably better.

Second, if the initial doses of onion are sufficiently diluted, there will be very little aggravation at all before improvement sets in. In fact, the homoeopaths see dilution to infinitesimal degrees as a necessary part of the preparation of their medicines. It is embodied in the other important axiom for treatment; the Law of the Minimum Dose. This states that the most effective dose for a disorder is the minimum amount necessary to produce a response. Give one dose only of the diluted substance, the homoeopaths say, and then wait for a favorable reaction. Having produced the desired improvement, give a second dose only when improvement stops.

It is this dilution of homoeopathic medicines which has been the greatest obstacle to their more universal acceptance. The process is known as potentisation, and involves a sequence of progressive dilution and a rhythmic shaking, termed succussion. In the normal case, 1 part of the source substance is added to 9 parts of water and shaken rhythmically. This is known as a 1x (decimal) dilution, or 1 part in 10. One part of this is then taken and added to another 9 parts of water, and again succussed, to give a 2x dilution, or 1 part in 100. Similarly, a 3x dilution is 1 part in 1000. These dilutions, also known as potencies, can be repeated an large number of times.

Dilutions are also made on a centesimal scale, or 1 part in 100, yielding 1c, 2c, and so on. It needs only a little mental arithmetic to appreciate that a dilution procedure of this type (either decimal or centesimal) rapidly disperses the original substance. Figure 1 gives a summary of the potencies, and their corresponding dilutions.







Summary of the homoeopathic potencies
showing concentrations of the source drug.

The Avogadro Limit

In practice, a convenient classification of the dilutions is usually used:

Low potencies: 1x to 30x, or 1c to 15c.

Medium potencies: 30c to 200c.

High potencies: Above 200c.

Hence the low potencies have been diluted least, and may still contain significant amounts of the source drug. But at 12c or 24x what is known as the Avogadro limit is reached, and at this concentration it is unlikely for even a single molecule of the original drug to be still present in one liter of the preparation. Yet the Avogadro limit occurs in the low potency range, and the homoeopaths maintain that, contrary to expectations, the power of the medicine increases as the potency increases. So there is very little doubt that many patients treated with high potencies receive nothing but water.

The Homoeopathic Dilutions

While the toxicity of such medicines is obviously very low, their efficacy has been seriously questioned, as dilutions above 12c can be dismissed on pharmacological grounds as completely inert. Yet potencies in the medium to high dilution range are the normal working area of homoeopathy, and many striking cures have been claimed. The first and obvious response is to claim that the action in successful cases is purely placebo, and the medicine is useful only in the suggestible and the gullible. Not so, maintain the homoeopaths, who claim cures on infants, animals, unconscious patients, those with infectious diseases, and those with deep seated chronic disorders. In addition, the clinical trials are impressive. So the medical plot thickens.



Clinical Trials

The early homoeopaths were all trained allopaths, and once having been convinced of the effectiveness of homoeopathic medicines, felt no need to prove anything to anybody. After all, they had the training to use whatever medicine they considered appropriate for their patients. It was also expedient to make as little noise as possible about their use of a medicine which was already regarded as suspect within their own ranks. In any case, most of their research time was spent on provings, in order to expand the number of known and useful medicines, and very little on clinical trials.

As a result, it took an event of considerable magnitude to bring the medicine out into the open, and the European cholera epidemic of 1832, two years before Hahnemann's death, was just such an occasion. By the accounts of all observers, the homoeopaths had a far higher recovery rate than the allopaths, and it is recounted that in Paris, the price of the homoeopathic medicine for cholera increased 100-fold. In Russia (where it is said the epidemic originated), the report from the Consul General showed that of the 1,270 cases treated homeopathically, 1,162 recovered, and only 108 died, giving a mortality rate of less than 10 percent. By contrast, the mortality rate from allopathic treatment was 60 to 70 percent.

Following the homoeopathic success in the epidemic, medical interest in homoeopathy increased at a rapid rate, and by the time of the next European cholera epidemic in 1854, the London Homoeopathic Hospital was already established. Its facilities were turned over entirely to the treatment of cholera victims, and the results were impressive. The homoeopathic death rate was 16.4 percent, compared to the allopathic death rate of 51.8 percent. Similar successful figures were reluctantly reported by a number of other countries. Detailed returns for Britain had to be made by all hospitals and practitioners as to treatment and results in cholera, and the totals submitted by the British Medical Council in their Blue Book of Statistics. However, the figures from the Homoeopathic Hospital were deliberately omitted, and were only produced after considerable protest. The official reason for the omission was that inclusion of the homoeopathic figures "would give an unjustifiable sanction to an empirical practice, alike opposed to the maintenance of truth and the progress of science."

This prejudiced and bigoted reaction to the success of homoeopathic medicine is typical of the problem which has plagued the advance of science for many centuries. Orthodox medicine, in particular, is well known for its poor track record in meeting innovative change and research breakthroughs with the proper degree of scientific detachment and quiet encouragement. Even within their own ranks, some of the greatest of innovators, such as Lister, Jenner, and Harvey, suffered ridicule and professional ostracism over discoveries which later became mainstays of medical practice. In reaction to homoeopathic successes, the modern orthodox call has been for more clinical trials. Give us controlled trials, many allopaths have said, and if successful, we will accept the medicine.

Since that time, a number of clinical trials have been run, but many of them with poor controls. Some of the better run trials are summarized here briefly. Those looking for a more complete list could do no better than the excellent review of Scofield.

Mustard Gas

The best controlled of the early clinical trials was conducted jointly in London and Glasgow during the second world war, to find a method of prevention and treatment of mustard gas burns. Mustard gas in the 30c potency, given as a preventative, reduced the incidence of deep and medium burns significantly. The remedies Rhus tox and Kali bich also gave statistically significant results in treatment.

Rheumatoid Arthritis

More recent trials were conducted in 1978 at the Glasgow Homoeopathic Hospital, now emerging as a stronghold of homoeopathic research. Gibson and co-workers conducted a double-blind comparison of a range of homoeopathic remedies (matched against the individual symptom pictures), and compared the responses to those of salicylates and placebo in the treatment of rheumatoid arthritis. They showed that the patients who received homoeopathic remedies responded statistically better than those who received salicylates; moreover 42 percent of the homoeopathic group were able to discontinue all other treatment during the year.

Objections to the method of trial led to a more rigidly designed trial in 1980, where patients were given either a homoeopathic medicine or placebo, but were allowed to continue with their orthodox anti-inflammatory drugs. The homoeopathic group showed significant improvement as judged by a number of tests, as compared to the patients who received placebo. It was noted that homoeopathy was a safer and no less effective alternative to present day second line drugs in the treatment of rheumatoid arthritis.

Hay Fever - The Crack Widens

One of the most recent clinical trials, and certainly the most tightly controlled to date, was conducted in 1986 at the Glasgow Homoeopathic Hospital by Dr David Taylor Reilly, an allopath by training. The claim that homoeopathic medicines are placebo was tested in a randomized, double-blind, placebo-controlled trial. The effects of a homoeopathic preparation of mixed grass pollens (30c potency, no molecules of the original pollen remaining) was compared with those of placebo in a total of 144 patients with active hay fever. The homeopathically treated patients showed a statistically significant reduction in symptoms as assessed by both patient and physician. No evidence emerged to support the idea that placebo action explains the clinical response to homoeopathic remedies.

The publishing of this latter paper in the Lancet, arguably the most prestigious medical journal in the world, indicated the depth of penetration of homoeopathic medicine into the allopathic world. The controversy it produced indicated the degree of crystallization of the collective allopathic brain. Here at last was proof positive in the much upheld double-blind trial, yet the collective reaction was less than positive. Although some of the more far-sighted of the correspondents suggested the possibility that a new chemistry and a new physics had been born, the reliance on pharmacology in the allopathic way of thinking showed its dominance. Reactions to drugs are caused by molecules of drug substance interacting with various body components, the thinking goes, and if there are no drug molecules in a medicine then there is no reaction aside from placebo effects. The experiment was simply testing one placebo against another. The fact that statistical significance was obtained for one of the `placebos' was apparently deemed of no consequence, and indicates that the issue may not be a scientific issue at all, but more an economic and emotional one.

Pharmacological Support

Logically, one of the first areas to investigate for support (or the lack of it) in homoeopathy is the area of pharmacology, or drug action. And contrary to expectations, some surprising support is appearing.

Ask a pharmacologist about the biological effect of very low concentrations of common substances on living organisms and the answer will be that there is typically very little or zero response. Ask for some theoretical backup, and in short order you will find yourself confronted by one of the pharmacological tools of trade, the Dose - Response Curve. In brief, the curve illustrates one of the rules of thumb in drug use: that an increased dose of a drug will give an increased effect, while a lowered dose of a drug will give a reduced effect, and a very low dose will give no effect at all.

A glance at the curve in Figure 3 will show that the pharmacologically recommended dose of a drug lies in the area of the ED50, the dose which produces 50% of the total or maximal effect. The homoeopathic area of interest, on the other hand, lies at the very start of the curve, in the area of the so-called threshold dose.


The area of the threshold dose is usually avoided in standard pharmacological drug testing, for two reasons. The first is that the threshold dose lies some distance from the area of the ED50, so investigating this area for drug reaction is basically a waste of time. But the other reason is far more interesting. The threshold dose is an area where paradoxical and contradictory results are obtained, not easily explained in conventional terms. Again, the easy answer is to simply avoid it in experimentation. But the bottom line is that for many years the pharmacologists have known of the strange results obtained in the threshold dose area, but have simply chosen to ignore them. In doing so, they had unwittingly withdrawn orthodox support for an entirely different field of medicine.
It is interesting that one of the very earliest laws of pharmacology, known as the Arndt - Schulz Law, had already expressed the homoeopathic effect. Formulated by Arndt in 1888, and restated by Hueppe a few years later, the law set the groundwork for what should have been a side-by-side development of allopathic and homoeopathic medicine in the following century. It states: For every substance, small doses stimulate, moderate doses inhibit, large doses kill.

Allopathic medicine, with its emphasis on moderate drug doses, works in the inhibitory part of the scale. The result is seen in the typically inhibitory medicines produced: antihistamines, antibiotics, antacids, cough suppressants and so on, laying the basis for the so-called `suppressant' effect of drugs.

Homoeopathic medicine, on the other hand, begins at the stimulatory end of the curve, and moves to the left, into the smaller and smaller dose range. Its emphasis is on the stimulation of the body's natural balancing mechanisms, as seen in its philosophy of the natural regeneration of the body through rebuilding of vitality, a concept also in close agreement with naturopathic thought.

The pioneering work of Boyd bound the worlds of homoeopathy and Arndt-Schulz together in the early 1940s with a series of tightly controlled experiments, and set the stage for work much later on as to how homoeopathic medicine may work. Boyd worked with the enzyme malt diastase, which was already known to be inhibited by crude doses of the salt mercuric chloride, and measured its speed in the hydrolysis of starch. He also used a number of homeopathically prepared dilutions of mercuric chloride, including a batch at 61x, where there was no likelihood of any of the original salt remaining - it was pure water. He also worked with distilled water as a control. He showed that crude doses of mercuric chloride inhibited diastase activity, as was already well known, and that distilled water had no effect. But he also showed, with statistically significant results, that mercuric chloride 61x accelerated diastase activity.

Now this experiment had a number of ramifications, besides supporting the Arndt-Schulz Law. If there was no mercuric chloride in the 61x potency, the it should have reacted the same as distilled water. If, on the other hand, there was a contamination of mercuric chloride somehow in the test doses, then the activity of the enzyme should have decreased. Instead it did neither, but increased, from the laboratory point of view, homoeopathic medicines not only had been showed to work according to the Arndt-Schulz Law, but had been shown to affect enzyme action.























Hormesis: The New Breakthrough

Look up the Arndt-Schulz Law in a modern textbook of pharmacology, and you will be lucky if you find it mentioned, let alone discussed. It died out of the textbooks as the allopathic interest moved further into the inhibitory part of the Arndt-Schulz curve, and as the pharmacological Dose - Response curve avoided the area of the threshold dose. It appeared that, for all its promising origins, theoretical support for homoeopathy had died a natural death.

Recently, however, further support for homoeopathic medicine has come from a most unlikely direction: the field of toxicology, or the action of poisons. Beginning in 1960, data began to accumulate that poisonous substances were having two effects on living organisms(5). At high doses they inhibited metabolism and ultimately caused death, as was well known. But at low doses they exerted a stimulating effect, a response totally unexpected and not explainable by current medical science. Recently the trickle turned to a torrent, as toxicologists turned to examine the new phenomenon of hormesis, the name given to the stimulatory effect of low levels of usually poisonous substances. The Arndt-Schulz Law had not died: it had simply resurfaced with a new name.

The research results are incomplete, but the trend is inescapable. Evidence from experiments, both human and animal, shows hormesis as an effect occurring in all biological domains tested, with growing research support. It demonstrates that all substances (including pesticides and carcinogens) which show an inhibitory effect at high concentrations, have a stimulatory effect at low concentrations.

Typical Concentration-Response Curves Developed in Hormesis Research

















The alpha curve is the most expected pattern, and is assumed to describe the actions of drugs in humans as the concentration moves from low concentrations to progressively more inhibitory ones. This curve is a tentative one, and is assigned to those drugs which have not yet been fully tested for a stimulatory response.

The beta curve was the most frequently observed pattern, and accounted for the human reactions to the bulk of the drugs tested. It shows a typical curve as predicted by the Arndt-Schulz Law, but (understandably) was not tested in toxic and lethal dose ranges.

The two other curves the gamma and delta forms, were recorded where data was available for biological response at lower dose ranges. However data points for these ranges are generally less available, so the validity of these curves is unknown until further data is available.

Homoeopathic research has consistently produced results showing the basic curve structure of hormesis and the Arndt-Schulz Law. But the research goes further: as the drug substance is progressively diluted, the biological reaction alternates between stimulation and inhibition, as given by the hormesis gamma and delta curves. This periodic behavior is called rhythmicity by the homoeopaths, and represents one of the several great unexplained phenomena in homoeopathic action. But one factor is established: as the dilutions become extreme and the concentration of the source drug approaches zero, the biological reaction will also fade out unless the diluted solution is succussed in accord with traditional homoeopathic practice.



A typical rhythmicity curve of the homoeopathic remedy Prunus Spinosa

The implications of hormesis are enormous and deserve a story of their own, but a few points here may give future directions.

: Pesticides which are toxic to pests at high concentrations can cause a proliferation of their growth at lower concentrations, such as can occur in rainwater run-off and collecting river systems. The ecological value of their use will tumble.

: Any substance which causes cancer will likewise be shown to be anti-cancer in its action at a lower dose range.

: The present tactic of various health departments in this country of giving a herb in high doses to experimental animals (and then banning it in all dose ranges when tumors form) will become counterproductive. Any herb which causes cancer in high doses will be shown to protective against the same cancer in low dose ranges, suitable for human intake.

How Does Homoeopathy Work?

Central to the issue of medical acceptance of homoeopathy is the clarification of its mechanism of action. In particular, is there a model which adequately explains its clinical effectiveness and the successes of the trials?

In the development of a workable model, the research thinking has gone something like this: Given that the medicine is effective even when it can be shown that there is no likelihood of any molecules left in a particular dose (due to dilution), then the effect of the dose must lie with the water molecules themselves, since that is all that is left. Water itself can be assumed to have no effect in this case, since the dose is small, and the effect would always be the same. The answer must lie within the water molecules, and the only real possibility is in the type of energy that the molecule has stored.

Energy storage within molecules in biological systems lies within the realm of biophysics rather than biochemistry. Biophysics is a new field, having become established only within the last twenty years or so. It is not yet included in medical curricula in universities to any great extent, and is only now beginning to make its mark in the biological sciences. Small wonder, therefore, that the established medical world knows little of its existence, or the promise it holds in explaining the action of the medicines of energy, such as homoeopathy, acupuncture, psychic and spirit healing, and radionics.

Energy Storage

Molecules such as water can store energy in four different ways - kinetic, spin, vibration and electronic excitation. Some storage modes can store more energy than others, and we will start at the lowest, least energetic mode, which is kinetic energy, or energy of motion. A molecule stores kinetic energy by virtue of its speed. It is this storage in gases and liquids which causes pressure (such as air pressure) by the continual collision of the molecules with surfaces like our skin, and also causes the bulk of chemical reactions to occur. At room temperature, the energy which these molecules contain is low, compared with other states. It is unsuited to homoeopathic medicine since the energy is constantly altered by collision, and so any energy stored is degraded.



















Energy Storage In Molecules

Spin and Microwave Cooking

Spin energy is found in gases and liquids, but not in solids, where the stronger attractions between molecules prevents rotation. It is also not found in water until about 420C, a factor of considerable importance to living organisms, composed as they are of up to 90 percent water, with humans being about 40 percent. Heating up water to about 42 degrees causes sufficient disruption of the molecular attraction between molecules to allow spin to occur, and that's precisely the temperature at which humans start to die. Life processes in general seem to keep a safe distance from the temperature band of 42 to 45 degrees.

Spin energy in molecules corresponds to microwave radiation, which is one reason why this radiation is lethal. It is also an indication of the potential power of energy storage in this mode - strong enough to cook food. But it is unsuited to homoeopathic medicine, since at room temperature, the spin storage state in water has not become active.

Electronic Excitation

At the top end of the scale is electronic excitation, which is the stuff powering lasers, of great strength and intensity. Excite the electrons circling the component molecules up into higher orbits and energy is stored. Drop them down together, and a pulse of light is given out. It may be of sufficient strength and power to burn a hole through a razor blade, cut tissue in surgery, or stop an army tank - it depends on what molecules are used, and how strongly the electrons are excited. It is not suitable for homoeopathic medicine, because the excited electrons are unstable, and will decay in a matter of fractions of a second.

Vibratory Storage

Standing midway between the cooking power of microwave and the destructive power of lasers stands vibratory energy. Although it has an accepted place in physics as a means of storing energy, it has had a chequered career in medical science because of its association with trance mediums, psychic phenomena and extrasensory perception. Vibratory energy can be found in molecules throughout all three states of matter - solid, liquid and gas. It is responsible for phenomena such as the expansion of metals when heated, and the transfer of heat by conduction. Vibratory motion of a molecule increases when the molecule absorbs energy, and can re-radiate it at a later date, usually in the infrared part of the spectrum, where heat is also found.

It is in the storage of vibratory energy in water molecules during the succussion process that homoeopathic medicine places many of its hopes for a scientific explanation of its action. It is proposed that during the collision process, vibratory energy is exchanged between the source drug and the water, and that the water is left with a vibratory imprint of the drug. Further succussion makes the imprint deeper, which explains why the medicines are regarded as acting more strongly as the dilution increases. Furthermore it is not just energy which is being stored, it is proposed, but information, differing from one remedy to another depending on the source substance used, with every substance leaving a different vibratory signature in the water molecule. In this way homoeopathic medicine is seen as carrying information into the body when it is taken in dose form, perhaps as biological instructions.

If water molecules were dissociated from each other at room temperature, any vibratory energy stored would quickly degrade. But at 250C, about 70% of water molecules are incorporated into a stable hexagonal lattice structure, capable of storing a considerable amount of vibratory energy before it breaks up. But storage of vibratory energy causes structural changes, because any molecule which absorb energy will always change its shape. So a convenient way of telling if this particular model was correct was to examine homoeopathic water for structural changes.

A number of workers over the years have shown that both high and low potency homoeopathic medicines show structural changes in the water they contain. It was additionally shown that in order for the structural changes to occur, two things must happen. First, there must be a source drug to begin with; that is, you can't make a homoeopathic medicine from water alone. Secondly, you must succuss the remedy as it is diluted stepwise, in the rhythmic shaking manner used by the homoeopaths for many years. Only when these two processes are included will structural changes show.



Certainly one of the most visually impressive experiments to test the possibility of structural changes was carried out recently, involving ice crystals. Ice crystal structures are very good mirrors of the energy status of their component water molecules. It is why, for instance, you will never find two identical snowflake patterns, for each is formed under slightly different conditions. In the experiment, different potencies of the homoeopathic remedy Pulsatilla were frozen at -100C, and photographed under polarized light to show any changes in the ice crystal structure. The results are strikingly beautiful, and the changes in crystal size as the potencies increase indicate increased energy storage in vibratory modes.

Ice Crystal Photos Here

Benveniste - Champion or Charlatan?

In one of the stranger episodes in the recorded history of scientific publishing, the prestigious British research journal Nature recently published experimental results which the editors say they consider utterly impossible. The typically indigestible title of the paper is "Human Basophil Degranulation Triggered by Very Dilute Antiserum Against IgE, and the conclusions it proposes have been similarly indigestible to the medical community. The main players in the experiment were a special type of white blood cell known as a basophil and an antibody, IgE. When basophils are normally exposed to this antibody, their chemistry and internal structure change, in a way that is easily checked by staining techniques. But what Benveniste and his colleagues found was that the changes occurred even when the antibody was used up to the 120x potency, a dilution at which it is virtually impossible for even one molecule of the antibody to remain. The results also showed the familiar rhythmic changes in basophil reactions as the potencies increased, a factor still unexplained, even by homoeopaths. The deputy editor of Nature remarked that two centuries of observation and rational thinking about biology will have to be abandoned if the results stand, because they cannot be explained by existing physical laws.

The 13 member international research team headed by Professor Benveniste conducted their experiments after being challenged by two eminent French homoeopaths to disprove homoeopathy once and for all, by conducting a sensitive, tightly controlled experiment in an accredited research centre. The centre chosen was at the University of South Paris, where Professor Benveniste is a Research Director. "That was how it all started", he said. "They challenged us to prove them wrong, and we couldn't."

The furor surrounding this experiment has produced some unique reactions within the scientific community, and highlights an important question: how should the scientific establishment deal with anomalous findings which challenge the very roots of established thought? Nature journal had its own answer: it sent a fraud squad comprising one of its editors, a professional magician, and an investigator of scientific frauds from the USA to Benveniste's laboratories. Over a period of a week they criticized shortcomings in experimental design, studied the laboratory records, and interrogated the researchers. Finally, they failed to replicate the results in a double-blind trial, and declared the experiments "a delusion." Benveniste, not unexpectedly, considered the investigation a witch hunt and an outrage. "I welcome any explanation for our findings" he said, "but not this kind of crap."

The homoeopaths of the world, together with interested onlookers, can be assured that the matter will not rest there. Further interesting reading on the bizarre reactions to homoeopathic experiments on the part of the scientific and medical establishments will surface. Benveniste will undoubtedly be back, with a more tightly controlled experiment which will probably decide, once and for all, the future of homoeopathy.

References:

1. Bradford's Logic of Figures (1900): From Tyler: Homoeopathic Drug Pictures: Health Science (1978)

2. Tyler: Homoeopathic Drug Pictures: Health Science (1978)

3. Scofield: Homoeopathy and its Potential Role in Agriculture: A critical review. Biol Ag Hort: 2; 1-50 (1984)

4. Reilly et al: Is Homoeopathy a Placebo Response? Lancet: 881-886; Oct 18 (1986)

5. Townsend and Luckey: Hormoligosis in Pharmacology. JAMA 44; May 7 (1960)

6. Stebbings: Hormesis - The Stimulation of Growth by Low Levels of Inhibitors. Sci Tot Environ: 22: 213-234 (1982)

7. Bond et al: Microdosimetric Concepts Applied to Hormesis. Health Physics: 52 (5); 659-661 (1987)

8. Furst et al: Hormetic Effects in Pharmacology. Ibid. 527-530.

9. Sagan: What is Hormesis and Why Haven't We Heard of It Before? Ibid. 521-525.

10. Calabrese et al: The Occurrence of Chemically Induced Hormesis. Ibid. 531-541.

11. Brisbin et al: Sigmoid Growth and the Assessment of Hormesis. Ibid. 553-559.

12. Boyd: The Action of Microdoses of Mercuric Chloride on Malt Diastase. Brit Hom J; 31; 1-28 (1941) and 32; 106-111 (1942)

13. Coulter: Homoeopathic Science and Human Medicine. North Atlantic (1980)

14. Devenas, Benveniste et al: Human Basophil Degranulation Triggered by Very Dilute Antiserum Against IgE. Nature 33; P816 30 June (1988)
Theory of High Dilutions And Experimental Aspects by Rolland Conte, Henri Berliocchi, Yves Lasne and Gabriel Vernot. Translated and Co-edited By DYNSOL Ltd. Copyright Polytechnica 1996
A Summary By Paul Callinan M.Sc. N.D. D.Hom.

1. Introduction
Hahnemann and Homoeopathy
The French Team
2. The Contonian Model
The Mathematical Framework
The Physical Model
White holes
The Remanent Wave
Nuclear reactions
Hyperprotons
Potencies exhibit phase changes
Effects not due to contaminants
The Axioms of the Contonian model
3. Impact of Environmental Factors On The Remanent Wave
Temperature
Light
The amount of energy introduced by the succussion process
Moon phases
Gravitational forces
Other external influences such as ultrasound
4. The Nuclear Mechanism
5. Mechanism of the Effect On The Organism
6. The Future

1. Introduction

Hahnemann and Homoeopathy

Since its inception in 1796 by the German physician and experimental pharmacologist Samuel Hahnemann, homoeopathy has survived but is still a medical fringe discipline.

Hahnemann published his Organon in 1810, one year before Avogadro presented his hypothesis that there are 6.02 x 1023 molecules of a substance in 1 gram molecular weight. The solutions used in homoeopathy are both diluted and succussed, and in this case means that a substance has been diluted through a serial process in such a way that the dilution of the original drug may approach Avogadro's number and even exceed it. Since a one molar solution stepwise diluted to the 12c potency is unlikely to contain even one molecule of solute, and a basic tenet of homoeopathy is that solutions which have no active drug molecules can still have effects on the human organism, homoeopathy has met with substantial opposition from pharmacology.

Even 200 years after Hahnemann's discoveries, homoeopathy still lacks a theoretical foundation. Experimental studies on the nature of homoeopathic solutions have reported many changes: there are reported alterations in the infrared spectrum, nuclear magnetic resonance relaxation times, surface tension, dielectric constant, and a handful of other parameters. Biological studies have shown marked changes in enzyme speed, cardiac rate, muscle contraction and plant growth, to name but a few. Clinical trials are showing consistently better results as experimental design is improved. But experiments have been plagued by lack of reproducibility, and data could not be consistently interpreted. A number of models had been proposed to explain homoeopathic action, the most popular being the water memory model, but all models have been fairly speculative.

The French Team

Enter Rolland Conte and team from the field of economics. After many years of research in economics and macroeconomic forecasting, the French researchers Conte, Berliocchi, and Andras introduced in their book Nouvelle Economie Theorique a new mathematical theory known as Ether theory, and a new statistical tool known as Contonian statistics.

At the beginning of 1993 the team of Conte, Berliocchi, Lasne and Vernot applied these same mathematical techniques to the field of homoeopathy. They formulated a mathematical representation of high dilution effects using quantum field theory. In their book, Theory Of High Dilutions, they provide the results of their measurements and the rationale for its interpretation. The theory is innovative, high-tech, and breaks much new ground. The model they present may also explain, after so long, how homoeopathic medicine works.

Rolland Conte is a PhD in applied physics, with extensive experience in economics and macroeconomic forecasting, and the inspirational force behind Contonian statistics. Henri Berliocchi is a mathematician with a brilliant history, who provided the ether theory and the physico-mathematical model. Yves Lasne is a doctor of medicine, doctor of science, who provided the detection technology and research methodology, based on measurement of nuclear magnetic resonance and beta radiation. Gabriel Vernot is an engineer and computer scientist working in aerospace applications, and who provided the dedicated AAPDI software.

As early as 1985 Lasne had repeated earlier work showing evidence of changes in the infrared spectrum of homoeopathic solutions, and had demonstrated significant variation of T2 relaxation times in nuclear magnetic resonance studies over a range of centesimal dilutions. Lasne also reported evidence of radiation coming from the test samples. Contonian statistical analysis of NMR results and á-radiation began on a range of raw high dilution data. The analysis is run on dedicated Ecosem software called AAPDI, which stands for Analyse Activite Pharmacologique Dilutions Infinitesimales.

Analysis of infrared and NMR data produced a number, known as a Contonian frequency, even from data which at first glance was not reproducible or consistent with other experimentation. The Contonian frequency for a remedy is reproducible, given stable external variables. Every remedy has a unique Contonian frequency, offering a likely measuring tool by which quality control and formulation efficiency can be evaluated. In the history of homoeopathic manufacture, we have never had such a measuring tool; and as they say in science, if you can't measure it, it doesn't exist.

In essence, the French team have proposed a model for homoeopathic action based on classical quantum theory, a new mathematical theory, and a statistical tool for linking theory and experimental data. They have produced experimental verification of their model based on NMR work, and on beta-radiation measurements. The use of Contonian statistics has led to quantifiable results.

2. The Contonian Model

Mathematical and physical frameworks are presented which use classical quantum theory and quantum field theory. They require a strong background in physics and higher mathematics to appreciate their insights. The researchers report that their physico-mathematical model proposed is in accord with experimental results, and answers questions raised by considerations of high dilution and water memory.

The Mathematical Framework

The mathematical framework provides a theory for interpreting high dilution phenomena using quantum mathematics. It involves set theory and probabilistic modeling, and uses mathematical operators such as lagrangians in a way that would make your head swim. It involves:

. The use of real numbers as defined within the set theory known as the Zermelo-Frenkel theory.

. In handling classical quantum theory, another axiom, known as the choice axiom, is used in addition to the Zermelo-Frenkel theory.

. An additional axiom, known as Solovay's axiom, is used.

. A model of real numbers, known as Levy's model, is used jointly with Solovay's axiom and consideration of the Brownian motion of water molecules to establish the water memory model.

. A general mechanism for interpreting data, known as semiotic mechanics, has been introduced. This mechanism had been previously validated by Berliocchi, one of the authors, within his theory of ethers.

The Physical Model

Within the physical model, a number of events have been proposed and measured.

White holes

The disappearance of drug molecules during dilution leads to a dislocation in the solvent known as a singularity. This singularity has been termed a white hole. It can be thought of a small but highly energized area of space.

The remanent wave

The appearance of a singularity induces a wave which has been termed a remanent wave. It can be thought of as a set of ripples in a pond when a stone is dropped in. A remanent wave is always created when a particle disappears and leaves a white hole, and the number of remanent waves is proportional to the number of particles lost. When one continues the release at the same place and in a regularly spaced way, the waves produced are in phase and the amplitude increases. When no further stones are released, the ripples disappear within a certain time, and the wave energy is slowly released in the water as heat. This can be measured using standard equipment such as infrared absorption spectrophotometers.

Nuclear transformations

The appearance of a white hole and a remanent wave induces nuclear reactions in the high dilution medium. The creation of tritium, an isotope of hydrogen in water, results in the subsequent decay of a tritium neutron into an electron, a proton and a particle known as an anti-graviton which has no mass and no charge. Beta radiation can be detected. There are changes in NMR and in the infrared. Beta radiation is associated with electrons, while infrared is commonly known as heat. The energy of a remanent wave of a diluted-succussed solutions is around 1 KeV. For a high dilution of HNO3, measurement of the beta energy spectrum gives a frequency of 2.4 x 1017 Hz. This is a very high frequency, the wavelength range lying in a band from 1.25 and 10 nanometres. By comparison, the period of vibration of the helicoil nucleic acid chain of DNA is equal to 3.4 nanometres. This means that the DNA can act as a transmitter-receiver antenna. In essence, nuclear transformations in the test tube at room temperature are being proposed, although the efficiency is low. This was reported many years ago by Kerveran, another Frenchman, who wrote on biological transmutation within living organisms.

Hyperprotons

Above the Avogadro limit, no more white holes are produced, but there is a continued stimulation from succussion termed hyperproton expansion. Hyperprotons are seen as the missing link between chemistry and biochemistry. They are considered as particles that phase in and out of space-time. This is the basis of the relativistic and quantum theory of fields, the current theory in physics covering matter-energy interactions. The theory of hyperprotons uses the so-called second quantisation theory of Dirac for a free material particle in space-time: Dirac in 1933 proposed the emergence of a real electron from a sea of virtual electrons, sometimes called the second quantisation. Hyperproton expansion produces irradiation effects on surrounding matter, and reorganises the solvent structure. Such a field has been measured, and is calculated by renormalisation through the integral of Feynman. Hydrogen and oxygen lagrangians on data measured at 300 Mhz in NMR studies indicate a re-organization of the water structure. This provides evidence for the existence of a new quantum state, whose nature has not been fully elucidated.

Potencies exhibit phase changes

NMR studies show that the impregnation of lactose granules with succussed preparations produces an effective transfer but induces a phase displacement in the primary signal, the extent of phase displacement depending on the nature of the source drug and the potency. The general form of the phase displacement is a sinusoid. For sulphur dilutions around 300c, the displacement is 1800 out of phase. By contrast, histamine shows a very small phase displacement. Solutions which exhibit a 1800 phase displacement have an opposite effect on test systems (pea root length, frog leg metamorphosis) compared with solutions 00 out of phase. Hence stimulation of a test system at one dilution can be altered to inhibition at another dilution.

Effects not due to contaminants

An experimental approach was developed which demonstrated that the effects obtained were not due to the presence of contaminants in the diluent. The use of the contonian frequency indicates that the specific activity of high dilutions are reproducible within experimental error as long as external variables are controlled.

The Axioms Of The Contonian Model

As a result of these findings, two axioms have been formulated:

Axiom 1

The dilution-succussion process induces an effect which can be directly measured by physical and biological experiments.

Axiom 2

An informational message will be produced only if at least one substance exists in the diluent at the start of the process.

3. Impact of Environmental Factors On The Remanent Wave

Contonian frequency calculations indicate that the specific activity of high dilutions is reproducible at any time provided that external variables are controlled, such as:

. Temperature.

. Light.

. The amount of energy introduced by the succussion process.

. Moon phases.

. Gravitational forces.

. Other external influences such as ultrasound.

Some of these findings come as no surprise, as they appear to validate some issues known to the profession by experience.

. The sensitivity of homoeopathic medicines to light and temperature is well accepted amongst the homoeopathic profession.

. More surprising is the sensitivity to factors such as the phases of the moon and changes in geomagnetic flux. However it has been said by many homoeopaths that some remedies are better given at particular phases of the moon.

. It has also been suggested that homoeopathic medicines do not travel well because it involves moving though the magnetic field of the earth.

. It is also worth mentioning that the sensitivity of manufacture of high dilutions to changes in geomagnetic flux and gravitational flux was predicted in the physical model by the appearance of an anti-graviton during beta emission.

The need for a consistent medicine to be manufactured in a machine where the succussion speed and stroke length are optimized and consistent has led to the patented development of a succussion device.

4. The Nuclear Transformation Mechanism

As previously proposed, white hole creation leads to an irradiation of diluted-succussed solutions due to a neutron type field induced by the remanent wave. This irradiation will create, on the one hand hydrogen isotopes deuterium (1 proton and 1 neutron) and tritium (1 proton and 2 neutrons), or on the other hand oxygen O17. The efficiency of this nuclear reaction is known to be low. With regard to tritium, the neutron splits and releases 1 proton and 1 á- electron and an anti-graviton.

Autoradiography techniques have shown á-radiation emitted from granules impregnated with a preparation of potassium iodide, with no radiation being detected from controls. For dilutions up to 12c, beta radiation is expected to predominate, seeing that the level of succussion is low.

In dilutions higher than Avogadro, no more white holes are created. Neutron disintegration releases energy into a medium which already has a high proton content. The protons are then transformed into hyperprotons, which are considered as virtual particles that can phase in and out of space-time. They may also appear within the space-time singularities as nuclear protons. These hyperprotons will stabilize one part of the diluent structure (a local effect) that will then be able to influence the non structured part of the diluent.

5. Mechanism of the Effect On The Organism

A quantum model called Theory of Universal Wave Function has been proposed, to describe the effect of high dilutions on living organisms. They have proposed that intoxication of an organism by a toxic solution such as CCl4 induces a deviation from a state of health as indicated by a vector, and a phase displacement. Treatment of the organism with a high dilution of the correctly chosen remedy with a counteracting phase displacement restores the organism to its original vector and a healthy state.

To illustrate this proposal, the effect of dilutions of thyroxin upon the metamorphosis of tadpoles of the grass frog were studied. When added to the aqueous medium, diluted and succussed thyroxin can inhibit or accelerate larval development of the forelegs, depending on the dilution. On the basis of phase displacements, it is suggested that when the thyroxin preparation is in phase with the larval organism, the thyroxin acts as a booster for the transformation from the two legged to the four legged stage. When the thyroxin preparation is not in phase with the larval development, it inhibits metamorphosis. It was also noted that different effects were produced in the organism, depending on whether the solutions were succussed or not.

The specificity of diluted-succussed solutions is remarkable, even if an enzyme system specific of a given diluted-succussed solution has not been found. Interaction between two remanent waves induces a generalized and fast action on the organism. When such an interaction does not occur, the solution simply has no impact on the organism. The specificity of the diluted-succussed solution takes place within phase space.

Substantial interest has been centered on the enzyme peroxidase, which is seen as decoding structures introduced by the dilution-succussion process and inducing a proton flow within the organism. This has substantial promise in the understanding of meridian flow structure within the organism, as well as shedding light on the findings of Boyd, nearly half a century ago, who showed that homoeopathic potencies altered the speed of the enzyme diastase.

The processes of elimination and heart beat within the human body are proposed to fulfill all the requirements of white hole emergence. Remanent waves are seen as pervading the whole organism in a normal state of health. Food denial or fasting for a short period is considered to improve the observation of the remanent wave. As a result, a person may be considered as having a remanent wave profile, a situation offering great promise in therapeutics.

6. The Future

Dr Conte and team are currently preparing a second book for publication. We can only plead for a glossary of terms in the next book, and wait for the benefits it offers for the future of homoeopathy and human medicine.

Paul Callinan M.Sc. N.D. D.Hom. is an Australian homoeopath, biophysicist and researcher who specializes in providing scientific support for natural medicines. He has proposed models for the mechanism of homoeopathic medicine in the research literature and at international seminars. He has written several books on homoeopathy, and is a contributing editor of Australian Wellbeing magazine. He works as a lecturer in homoeopathic medicine, and conducts a clinical practice in Bangalow, northern NSW.
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Some Homeopathic Remedies

There are more than 2,000 homeopathic remedies, mainly from plant and mineral sources, and a few from animal products, such as snake venom. There are also some made from diseased tissue, known as 'nosodes'. Here are just a few examples of commonly used remedies with a brief explanation of each.


Arnica

A flower remedy and perhaps the best known of homeopathic remedies. The number one first-aid remedy, it helps prevent bruising and deal with shock or fright. Excellent for accident victims and to help with recovery after surgery or childbirth.


Belladonna (Deadly Nightshade)

Often used as a fever remedy, particularly when there is very high temperature, redness and burning sensations. Symptoms can be violent and intense, and there may be delirium and hallucinations.


Calcarea Carbonica (Calcium from an Oyster Shell)

This remedy can be indicated for patients who are extremely sensitive to cold. There may be a dampness or clamminess, particularly on hands and feet. The body may be floppy and exhausted.


Gelsemium (Yellow Jasmine)

A good remedy for fright from anticipation, e.g. stage fright. It is also used when there is general prostration, with the limbs feeling too heavy to lift, so it is often indicated in slow developing colds and flus.




Ignatia (St. Ignatius’ Bean)

A major remedy for grief and shock - even hysteria. It is often used for a patient who has suffered bereavement, the ending of a relationship, financial loss or a miscarriage. The Ignatia patient tends to be introspective, brooding and melancholy, but their moods can be changeable.


Lachesis (Bushmaster Snake Venom)

Renowned as a remedy for jealousy and vengefulness. Physical symptoms include constriction of the throat, and a feeling of suffocation. The patient often cannot bear to have things around their neck, and may have a fear of snakes.


Natrum Muriaticum (Common Salt)

This remedy is associated very closely with suppressed anger and grief. The patient tends to be closed and unhappy, and actually feels worse for any attempts at consolation. On the physical level, there is a tendency to be chilly, with cold hands and cold feet.


Pulsatilla (Pasque Flower)

This is traditionally seen as a female remedy but can just as easily be appropriate for a male patient. On the emotional level, there is shyness and insecurity and a fear of being deserted. Physically, there may be abdominal pain and flatulence. Thirstlessness is a key symptom.


Sulphur

The leading homeopathic skin remedy, often indicated in cases of eczema and other skin eruptions where there is redness, itching and burning. Sulphur is powerful at reversing the effects of suppressive medication.
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Clinical Studies - an Overview of Positive Homeopathy Research

An Overview of Positive Homeopathy
Research and Surveys
The European Network of Homeopathic Researchers
March 2005
This document has been produced by the European Network for Homeopathy Researchers (ENHR).
The ENHR was established in 2004 with support from the European Council for Classical
Homeopathy (ECCH). ECCH currently assists the ENHR in its secretarial work. The ENHR consists
of 35 individuals from 10 different countries involved in or with a special interest in homeopathy
research. The ENHR is open to membership for any individual involved or interested in homeopathy
research.
Purpose of the European Network of Homeopathy Researchers (ENHR):
• The primary aim of the ENHR is to contribute to improving homeopathy research for the
benefit of patients.
• A long-term objective of the ENHR is to contribute to carrying out international EU funded
research projects within the area of homeopathy research.
• The ENHR consists of researchers, research advisors and representatives of the homeopathy
profession as well as consumer/patient groups with an interest in the area of homeopathy
research.
• Members of the ENHR inform each other about homeopathy research that is in the planning
stages or being carried out, as well as published research articles.
Introduction
This document contains a sample of brief summaries of positive homeopathy research, together with
the full references. Additional information may be found in the document entitled 'Facts about
homeopathy and other CAM therapies’ (an ECCH document), and on the enclosed list of website
addresses. Readers are recommended to read the full research articles in order to acquire a more
profound knowledge base of research that has been undertaken.
Contents Page
Use of homeopathy and other CAM therapies 2
User surveys showing patient satisfaction with homeopathic treatment 2
Meta-analyses 3
Key trials and surveys 5
Diarrhoea in children 5
Respiratory tract complaints 5
Musculo-skeletal problems 7
Hayfever, asthma and perennial rhinitis 8
Female complaints 8
Other notable trials 9
Cost benefit 9
Basic research 10
Treatment of animals 10
Research website addresses 11
An Overview of Positive Homeopathy Research and Surveys, ENHR, March 2005 Page 2 of 12
USE OF HOMEOPATHY AND OTHER CAM THERAPIES
Homeopathy is being practised in 40 out of 42 European countries.
The Legal Situation with Regard to the Practice of Homeopathy in Europe, revised report, June 2002,
European Council for Classical Homeopathy. Legal Status of Traditional Medicine and
Complementary/Alternative Medicine: A Worldwide Review, World Health Organization, 2001.
Homeopathy is the most frequently used CAM therapy in 5 out of 14 surveyed countries in Europe
and among the three most frequently used in 11 out of 14 surveyed countries.
Norges offentlige utredninger, NOU 1998:21 Alternativ medisin. (Official report published by the
Norwegian Department of Health. Available at:
http://odin.dep.no/hd/norsk/publ/utredninger/NOU/030005-020019/index-ved005-b-n-a.html)
Ot.prp. nr. 27 (2002-2003). Om lov om alternativ behandling av sykdom mv.
Public interest for and acceptance of alternative treatment increases in most European countries.
Percentage of the population using alternative treatment varies from 18 to 71 % depending on country.
Ot.prp. nr. 27 (2002-2003). Om lov om alternativ behandling av sykdom mv.
Homeopathy is officially recognised and included in the national health system in a number of
countries within and outside of Europe.
Legal Status of Traditional Medicine and Complementary/Alternative Medicine: A Worldwide Review,
World Health Organization, 2001.
Between 1/4 and 1/5 of all EU citizens use homeopathic medicines (EU Commission statement).
Resolution on the Commission report to the European Parliament and the Council on the application
of Directives 92/73/EEC and 92/74/EEC on homeopathic medicinal products (COM(97)0362 - C4-
0484/97)
Information to be included
Menniti-Ippolito, F., Forcella, E., Bologna, E., Gargiulo, L., Traversa, G., & Raschetti, R. 2002, "Use
of unconventional medicine in children in Italy", Eur.J.Pediatr., vol. 161, no. 12, p. 690.
USER SURVEYS SHOWING PATIENT SATISFACTION WITH HOMEOPATHIC TREATMENT
Seven out of ten patients visiting Norwegian homeopaths reported a meaningful improvement in their
main complaint 6 months after the initial consultation.
Steinsbekk, A. Patients' assessments of the effectiveness of homeopathic care in Norway: A prospective
observational multicentre outcome study. Homeopathy, Volume 94, Issue 1, January 2005, Pages 10-
16.
One year after their first visit to a homeopathic clinic, 609 patients were asked to rate their general
health compared with a year ago. 73.5 % reported a marked or moderate improvement in their health
status.
F. Attena et al. Homeopathy in Primary Care: self reported change in health status. Complementary
therapies in Medicine Vol 8 No 1. March 2000.
A study of 829 patients treated with homeopathic medicines, where conventional treatment had been
unsatisfactory or contraindicated. 61 % had a substantial improvement with homeopathy.
Sevar, R. Audit of outcome in 829 consecutive patients treated with homeopathic medicine. British
Homeopathic Journal Vol 89 No.4. Oct 2000.
An Overview of Positive Homeopathy Research and Surveys, ENHR, March 2005 Page 3 of 12
USER SURVEYS SHOWING PATIENT SATISFACTION WITH HOMEOPATHIC TREATMENT
A survey of more than 900 patients treated homeopathically showed substantial improvement in
quality of life over the first 6 months after treatment and this effect remained more or less stable over
the following years.
Güthlin C, Lange O and Walach H. Measuring the effects of acupuncture and homoeopathy in general
practice: An uncontrolled prospective documentation approach. BMC Public Health 2004, 4:6.
British prospective survey of homeopathic treatment of 223 patients, 1996. 90% improvement or
more: 32%. 60% improvement or more: 65% 50% improvement or more: 72%.
Report on NHS practice-based homoeopathy project. Analysis of effectiveness and cost of
homoeopathic treatment within a GP practice at St. Margaret's Surgery, Bradford on Avon, Wilts.
Elizabeth A Christie, Andrew T Ward ISBN 1 901262 006
British prospective survey of homeopathic treatment of 160 patients, 1994.
Very positive effect: 73%. Some effect: 27%. No effect: 0%.
Report on a Homoeopathy Project in an NHS Practice. Covering 18 month period from February
1993 to August 1994. Elizabeth A Christie, Andrew T Ward,. Reprinted February 1997.
British prospective survey of homeopathic treatment of 37 patients suffering from psychological
complaints, 1998. Very satisfied: 81%. Satisfied: 16%. Not satisfied at all: 3%.
Homoeopathy within the NHS. Evaluation of homoeopathic treatment of common mental health
problems. 1995 - 1997. Alistair Dempster,. Rydings Hall Surgery, Brighouse, West Yorkshire. ISBN
No 1901262014.
Retrospective survey of homeopathic treatment, Danmarks Farmaceutiske Højskole, 1995.
73% of patients stated they improved after homeopathic treatment.
Andersen HE, Eldov P. Klassisk hom?opati - og dens brugere. Institut for Samfundsfarmaci,
Danmarks Farmaceutiske H?jskole. 1995. Andersen, Helle Egebjerg. En unders?gelse af Klassisk
Homøpati. Teorier, praksis og brugererfaringer. 1999. ISBN 87-987279-0-7
The effect of homeopathy, acupuncture and osteopathy. Result: 89% of patients stated they
experienced positive effect from the treatment. Particularly clear effect on reduction of pain, increased
vitality, ability to function socially and with regards to limitations at work and in daily activities
influenced by physical problems. Homeopathy was particularly effective for patients suffering from
arthritis, hayfever, atopic asthma and skin complaints.
Richardson J. Quasi-randomised control trial to assess the outcome of acupuncture, osteopathy and
homoeopathy using the short form 36 item health survey. Health Services Research and Evaluation
Unit, The Lewisham Hospital NHS Trust. December 1996.
META-ANALYSES
A meta-analysis is a means of combining results from more than one trial to look for overall trends.
(NB! In general complicated research terminology such as OR, CI, and words such as significant or
randomized should only be used in communications with people who will understand such
terminology. Otherwise stick to what can be understood by all, e.g. A survey of all the high quality
research that has been carried out clearly shows that homeopathy is effective.)
Information to be included
Jonas, W. B., Kaptchuk, T. J., & Linde, K. 2003b, "A critical overview of homeopathy",
Ann.Intern.Med., vol. 138, no. 5, pp. 393-399.
Cucherat, M., Haugh, M. C., Gooch, M., & Boissel, J. P. 2000, "Evidence of clinical efficacy of
homeopathy. A meta-analysis of clinical trials. HMRAG. Homeopathic Medicines Research Advisory
Group", Eur.J.Clin.Pharmacol., vol.. 56, no. 1, pp. 27-33.
An Overview of Positive Homeopathy Research and Surveys, ENHR, March 2005 Page 4 of 12
META-ANALYSES SHOWING THAT HOMEOPATHY WORKS
A systematic review of results from 93 substantive RCTs was carried out by Robert Mathie (2003). It
concludes that of the 35 different medical conditions covered by these trials the weight of evidence
favours a positive treatment effect in 8: childhood diarrhoea, fibrositosis, hayfever, influenza, pain
(miscellaneous), side-effects of chemotherapy or radiotherapy, sprains and upper-respiratory tract
infections.
Mathie, R. The research evidence base for homeopathy: a fresh assessment of the literature.
Homeopathy 92: 84-91. 2003.
Meta-analysis of 89 trials of homeopathic medicine versus placebo. Result: significantly in favour of
homeopathy (OR 2,45 (95% CI 2,05-2,93)). This meta-analysis included 186 placebo-controlled
studies of homeopathy published until mid-1996, of which data for analysis could be extracted from
89. The overall odds ratio was 2.45 (95% confidence intervals 2.05-2.93) in favour of homeopathy,
which means that the chances that homeopathy would benefit the patient were 2.45 times greater than
placebo. When considering just those trials of high quality published in MEDLINE listed journals, and
with predefined primary outcome measures, the pooled odds ratio was 1.97 and significant. Even after
correction for publication bias the results remained significant. The main conclusion was that the
results "were not compatible with the hypothesis that the effects of homeopathy are completely due to
placebo". If the result of new trials were to show no difference between homeopathy and placebo, we
would have to add 923 trials with no effect with 118 patients in each in order to balance the two.
Linde K, Clausius N, Ramirez G, et al. Are the clinical effects of homoeopathy placebo effects? A
meta-analysis of placebo-controlled trials. Lancet 1997;350:834-43.
HMRG report with overview of clinical research in homeopathy, identified 184 controlled clinical
trials. They selected the highest quality randomized control trials, which included a total of 2617
patients for a meta-analysis. This meta-analysis resulted in a p-value of 0.000036 (which means that
results are highly significant) indicating that homeopathy is more effective than placebo. The
researchers concluded that the "hypothesis that homeopathy has no effect can be rejected with
certainty". Homeopathic Medicine Research Group. Report to the European Commission directorate
general XII: science, research and development. Vol 1 (short version). Brussels: European
Commission, 1996:16-7.
Of the 105 trials with interpretable results, 81 trials indicated positive results. Most studies showed
results in favour of homeopathy even among those randomized controlled trials that received highquality
ratings for randomization, blinding, sample size, and other methodological criteria. They came
to the following conclusion: "The amount of positive evidence even among the best studies came as a
surprise to us. Based on this evidence we would readily accept that homeopathy can be efficacious, if
only the mechanism of action were more plausible. The evidence presented in this review would
probably be sufficient for establishing homeopathy as a regular treatment for certain indications".
Kleijnen J, Knipschild P, Ter Riet G. Clinical trials of homoeopathy. British Medical Journal.
1991b;302:316-23.
Meta-analysis of 105 articles on laboratory research. Result: positive effect 50% more frequently than
negative effect among trials of highest methodological quality. (1994)
Linde K. Jonas WB, Melchart D, Worku F, Wagner H, Eital F. Critical Review and Meta-Analysis of
Serial Agitated Dilutions in Experimental Toxicology. Human and Experimental Toxicology.
1994;13:481-492.
A meta-analysis of three trials on homeopathic immunotherapy. Result: significant effect in favour of
homeopathic treatment.
Reilly D, Taylor MA, Beattie NGM, Campbell JH, McSharry C, Aitchison TC, Carter R, Stevenson
RD. Is evidence for homoeopathy reproducible? Lancet. 1994;344:1601-1606.
An Overview of Positive Homeopathy Research and Surveys, ENHR, March 2005 Page 5 of 12
KEY TRIALS AND SURVEYS
Diarrhoea in children
Treatment of acute childhood diarrhoea in Nicaragua
This trial involved 81 children aged from 6 months to 5 years in a randomised, double-blind trial of
intravenous fluids plus placebo versus intravenous fluids plus homeopathic remedy individualised to
the patient. The treatment group had a statistically significant decrease in duration of diarrhoea.
Jacobs J. Treatment of acute childhood diarrhea with homeopathic medicine: a randomized clinical
trial in Nicaragua. Pediatrics 1994; 93: 719-725.
Treatment of acute childhood diarrhoea, repeated in Nepal
In a replication of a trial carried out in Nicaragua in 1994, 116 Nepalese children aged 6 months to 5
years suffering from diarrhoea were given an individualised homoeopathic medicine or placebo.
Treatment by homoeopathy showed a significant improvement in the condition in comparison to
placebo.
Jacobs J., Jimenez M., Malthouse S., Chapman E., Crothers D., Masuk M., Jonas W.B., Acute
Childhood Diarrhoea- A Replication., Journal of Alternative and Complementary Medicine, 6, 2000,
131-139.
A meta-analysis of childhood diarrhoea trials
This meta analysis of 242 children showed a highly significant result in the duration of childhood
diarrhoea (P=0.008). It should be noted that the World Health Organisation consider childhood
diarrhoea to be the number one public health problem today because of the millions of children who
die every year from dehydration from diarrhoea.
J. Jacobs, WB Jonas, M Jimenez-Perez, D Crothers, Homeopathy for Childhood Diarrhea: Combined
Results and Meta-analysis from Three Randomized, Controlled Clinical Trials
http://homeopathic.com/articles/research/diarrhea_t.php
Respiratory tract complaints
Homeopathy versus conventional treatment in respiratory tract complaints
In an outcome study, 30 practitioners in four countries enrolled 500 consecutive patients with at least
one of three complaints: upper respiratory tract complaints including allergies; lower respiratory tract
complaints including allergies; or ear complaints. Of 456 patients, 281 received homeopathy and 175
conventional treatment. The primary outcomes criterion was response to treatment, defined as cured or
major improvement after 14 days of treatment. Results showed a response rate of 82.6% in the
homeopathy group compared to 67.3% in the group receiving conventional medicine. The authors
concluded that homeopathy appeared to be at least as effective as conventional treatment of patients
with the three conditions studied.
Riley D, Fischer M, Singh B, Haidvogl M, Heger M. Homeopathy and conventional medicine: an
outcomes study comparing effectiveness in a primary care setting. J Altern Complement Med 2001; 7:
149–159.
Homeopathy versus conventional treatment in otitis media
Prospective observational study, comparison of homeopathy versus conventional treatment in acute
otitis media. Conclusion: homeopathy should be first line treatment in acute otitis media. Results
showed median duration of pain of 2 days in the homeopathy-group and 3 days in the conventional
medicine group. 70.7 % of the children receiving homeopathic treatment did not have another ear
infection the next year and 29.3 % had a maximum of three ear infections within one year. 56.5 % in
the conventional medicin group did not have another ear infection the next year and 43.5 % had a
maximum of six ear infections the next year. Results showed that in the group receiving homeopathic
treatment only 5 out of 103 children needed antibiotics.
Friese K-H, Kruse S, Ludtke R, Moeller H "Homeopathic treatment of otitis media in children:
comparisons with conventional therapy". Int J Clin Pharmacol Ther. 1997; 35: 296-301.
An Overview of Positive Homeopathy Research and Surveys, ENHR, March 2005 Page 6 of 12
Acute otitis media in children
A study involving children suffering from acute otitis media suggests that a positive treatment effect
from homeopathy when compared with placebo in acute otitis media cannot be excluded. There were
fewer treatment failures in the group receiving homeopathy after 5 days, 2 weeks, and 6 weeks, with
differences of 11.4, 18.4, and 19.9%, respectively, but these differences were not statistically
significant. Diary scores showed a significant decrease in symptoms at 24 and 64 h after treatment in
favour of homeopathy (P<0.05).
Jacobs J, Springer DA, Crothers D. Homeopathic treatment of acute otitis media in children: a
preliminary randomized placebo-controlled trial. Pediatr Infect Dis J 2001; 20: 177–183.
Acute otitis media in children
In a trial of 230 children who were given homeopathic treatment to treat acute otitis media, pain relief
was achieved in 39% of the patients after 6 h and another 33% after 12 h. The resolution rates were 2.4
times faster than in placebo controls. No complications were observed and compared to conventional
treatment the homeopathic approach was 14% cheaper.
Frei H, Thurneysen A. Homeopathy in acute otitis media in children: treatment effect or spontaneous
resolution? Br Homeopath J 2001; 90: 180–182.
Glue ear in children
In a pilot study in children suffering from glue ear treated with homeopathy 75% had normal
tympanogram, compared to 31% in the group treated with conventional medicine. A higher proportion
of children receiving homeopathic treatment had a hearing loss less than 20 dB at follow-up, though
the difference was not statistically significant. The authors concluded that further research comparing
homeopathy to standard care is warranted; 270 patients would be needed for a definitive trial.
Harrison H, Fixsen A, Vickers A. A randomized comparison of homoeopathic, standard care for the
treatment of glue ear in children. Compl Therap Med 1999; 7: 132–135.
Acute sinusitis
In an uncontrolled clinical trial of 119 patients suffering from clinical signs of acute sinusitis were
treated using homeopathic medicines. Typical sinusitis symptoms, such as headache, pressure pain at
nerve exit points, and irritating cough, were reduced after a mean of 4.1 days of treatment. Ninety-nine
received only a homeopathic test medication, 20 patients were able to discontinue concomitant
medication at the first visit, and only one patient needed antibiotics. Average duration of treatment
was 2 weeks. At the end of treatment 81.5 % described themselves as symptom free or significantly
improved. No adverse medication effects were reported.
Adler M. Efficacy, safety of a fixed-combination homeopathic therapy for sinusitis. Adv Ther 1999;
16: 103–111.
An Overview of Positive Homeopathy Research and Surveys, ENHR, March 2005 Page 7 of 12
KEY TRIALS AND SURVEYS
Musculo-skeletal problems
Rheumatoid arthritis
Forty-six patients with rheumatoid arthritis received an individualised remedy or placebo in a 3-month
randomised trial. Both groups were allowed to continue standard anti-inflammatory drugs. After 3
months, the double-blind code was broken and remedies were given to members of the placebo group
in a single crossover study. Articular index, limbering up time, grip strength and pain all showed
statistically significant differences.
Gibson RG, Gibson SLM, MacNeill AD, Buchanan WW Homeopathic therapy in rheumatoid arthritis:
evaluation by double-blind clinical therapeutic trial. British Journal of Clinical Pharmacology 1980;
9: 453-459.
Osteoarthritis
In this trial, 65 sufferers of Osteoarthritis (OA) were split into 2 groups, and through a double blinding
process were given either a homoeopathic medicine or Acetaminophen, a commonly prescribed drug
for pain relief in OA. Researchers found that homoeopathy provided a level of pain relief that was
superior to Acetaminophen, and produced no adverse reactions.
Shealy C.N., Thomlinson P.R., Cox R.H., and Bormeyer V. Osteoarthritis Pain: A Comparison of
Homoeopathy and Acetaminophen. American Journal of Pain Management, 8, 3, July 1998, 89-91.
Fibromyalgia
A double-blind, randomised, placebo-controlled trial of individualised homeopathic treatment (LM
potency) versus placebo concluded that individualised homeopathy is significantly better than placebo
in lessening tender point pain and improving the quality of life and overall health of persons with
fibromyalgia.
Bell IR, Lewis II DA, Brooks AJ, Schwartz GE, Lewis SE, Walsh BT, Baldwin CM. Improved clinical
status in fibromyalgia patients treated with individualized homeopathic remedies versus placebo
http://rheumatology.oupjournals.org/cgi/reprint/keh111.
Fibrositis
In a randomised placebo-controlled trial of patients with fibrositis, only those patients in whom Rhus
toxicodendron was ‘unequivocally indicated’ were admitted to the study. After 1 month’s treatment,
there were highly significant improvements in objective and subjective parameters.
Fisher P. An experimental double-blind clinical trial in homoeopathy. British Homoeopathic Journal
1986; 75: 142-147.
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KEY TRIALS AND SURVEYS
Hayfever, asthma and perennial rhinitis
Reilly and colleagues have conducted a series of trials in patients with hayfever, asthma and perennial
rhinitis. Patients were given skin tests and remedies were chosen on the basis of reactivity. This design
allows individualisation whilst avoiding the issues of case-taking and the effect that this has on the
process. The results demonstrate a significant difference between the placebo and homeopathic groups
which is reproducible. (NB! Strictly speaking these are trials of isopathy.)
Anon. Reilly’s challenge (editorial). Lancet 1994; 344: 1585.
Reilly DT, Taylor MA. Potent placebo of potency? A proposed study model with initial findings using
homoeopathically prepared pollens in hay fever as a model. British Homoeopathic Journal 1985 ; 74:
65-75.
Reilly DT, Taylor MA, Campbell J, Beattie N, McSharry C, Aitchison T, Carter R, Stevenson R. Is
evidence for homoeopathy reproducible? Lancet 1994; 334: 1601-1606.
Reilly DT, Taylor MA, McSharry C, Aitchison T. Is homoeopathy a placebo response? Controlled trial
of homoeopathic potency, with pollen in hay fever as a model. Lancet 1986; ii: 881-886.
Taylor MA, Reilly D, Llewellyn-Jones RH, McSharry C, Aitchison T, Lancaster T, Vickers A.
Randomised controlled trial of homeopathy versus placebo in perennial allergic rhinitis with overview
of four trial series British Medical Journal 2000; 321: 471-476.
Female complaints
Polycystic Ovary Syndrome
36 women suffering from Polycystic Ovary Syndrome (PCOS), and fitting the mental picture of the
homoeopathic remedy Pulsatilla, were given Pulsatilla 6C, 4 hourly throughout the day for 2 weeks
after the end of menstruation, and this was repeated for 4 consecutive cycles. At the end of the trial 30
of the 36 women had no symptoms of PCOS and they had normal ovulating follicles and 4 of the 36
women became asymptomatic.
Sanchez-Resendiz J., Guzman-Gomez F., Polycystic Ovary Syndrome. Boletin Mexicano de
Homeopatica, 30, 1997, 11-15.
Pre menstrual syndrome (PMS)
In a randomized controlled double-blind clinical trial (1992-94) 19 women suffering from PMS were
treated individually with homeopathy. 90 % of the patients who had received homeopathic treatment
experienced more than 30 % improvement. Only 37.5 % of patients who received placebo experienced a
similar improvement. Sick-days before menses were reduced from 0.75 to 0 in the homeopathy-group,
and was unchanged in the control group. Use of conventional drugs was also reduced in the homeopathygroup.
Yakir M, Kreitler S, Brzezinski A, Vithoulkas G, Oberbaum M, Bentwich Z.
Effects of homeopathic treatment in women with premenstrual syndrome: a pilot study. Br Homeopath J.
2001 Jul ;90(3): 148-53.
Homeopathy and oestrogen withdrawal
40 out of 45 women with breast cancer withdrawing from oestrogen and then treated homeopathically,
experienced significant improvement in their primary symptoms, anxiety and depression, as well as
improvement in quality of life. Primary symptoms changed from 7.8 to 5.4, and from 7.2 to 4.1
(p<0.001). The homeopathic approach appears to be clinically useful in the management of oestrogen
withdrawal symptoms in women with breast cancer.
Thompson EA, Reilly D. The homeopathic approach to the treatment of symptoms of oestrogen
withdrawal in breast cancer patients. A prospective observational study.
Homeopathy. 2003 Jul;92(3):131-4.
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Homeopathy in menopausal complaints
In a prospective study 82 % of 102 patients reported improvement of menopause symptoms after
homeopathic treatment. Main symptoms noted were hot flushes and sweats, tiredness, anxiety,
sleeping difficulties, mood swings and headaches. Women referred to homeopathy were those who
either could not take hormone replacement treatment (HRT), for whom HRT was unsuccessful, who
did not want or who had to come off HRT. Mean length of homeopathic treatment was 5 months.
Relton, C. NHS Homeopathy Menopause Service. Outcome Study. In press.
Other notable trials
ME
A randomised double-blind trial involving 62 patients with ME, reported in some detail, found that
33% of patients in the group receiving homeopathic remedies showed definite improvement compared
with none in the placebo group.
Awdry R. Journal of Alternative and Complementary Medicine 1996; February, March, April.
Dengue haemorrhagic fever
Dengueinum 30 was administered to at least 39,200 people in the Delhi area during an epidemic of
Dengue haemorrhagic fever. Follow-up of 23,520 people 10 days later showed only 5 people (0.125%)
had developed mild symptoms, with the rest showing no signs or symptoms of the disease. (During
epidemics of dengue, atttack rates among susceptibles are often 40-50 %, but may reach 80-90 %,
World Health Organisation)
Central Council of Research in Homoeopathy. CCRH News 1996-1997.
Cost benefit
In a survey of 223 patients in an NHS General Practice, the number of consultations with general
practitioners was reduced by 70 % in a 1 year period. Expenses for medication were reduced by 50 %
when homeopathic treatment was made available.
Christie EA, Ward AT. Report on NHS practice-based homoeopathy project. Analysis of effectiveness
and cost of homoeopathic treatment within ad GP practice at St. Margaret’s Surgery, Bradford on
Avon, Wilts. September 1996. The Society of Homeopaths. ISBH 1 901262 006.
In a study of 351 adults suffering from allergies, 35.3% received homeopathic treatment, the
researchers concluded that alternative medicine is used widely for allergies by the general population
and is associated with considerable costs. This has freedom of choice and cost-benefit implications for
the healthcare system and health policy. The study also showed that alternative medicine users were
better educated than non-users, and assessed the results of alternative medicine as very good (28.6%)
or rather good (53.8%).
Schafer T, Riehle A, Wichmann HE, RingJ. Alternative medicine in allergies—prevalence, patterns of
use, and costs. Allergy 2002; 57: 694–700.
A study of the cost and effectiveness of homeopathy suggested that doctors practising homeopathy
issue fewer prescriptions and at a lower cost than their colleagues. The main costs for homeopathic
treatment are for consultations with each individual patient. Costs for the actual medications used are
relatively low, particularly when compared with conventional drugs.
Swayne J. The cost, effectiveness of homoeopathy. A pilot study, proposals for future research. Br
Homoeopath J 1992; 81: 148–150.
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Basic research
The effect of high dilutions
In a multi-centre study including four research centres in Europe the effect of high dilutions of
histamine (10-30 – 10-38 M) were confirmed. Researchers were able to document that high dilutions of
histamine inhibit human basophil degranulation. Results cannot be explained through molecular
theories.
Belon P, Cumps J, Ennis M, Mannaioni PF, Roberfroid M, Sainte-Laudy J, Wiegant FAC. Histamine
dilutions modulate basophil activation. Inflamm. Res. 2004; 53: 181-188.
The effect of high dilutions was documented in an experiment showing the effect of highly diluted
Belladonna on acetylcholine-induced contraction of the rat ileum. The model is reproducible and
highly recognised in ‘the scientific world’.
Bastide M (ed). Signals and Images. Kluwer Academic Publishers 1997: 161-170
Information to be included
Lorenz, I., Schneider, E. M., Stolz, P., Brack, A., & Strube, J. 2003, "Sensitive flow cytometric method
to test basophil activation influenced by homeopathic histamine dilutions", Forsch Komplementarmed
Klass Naturheilkd, vol. 10, no. 6, pp. 316-324.
Treatment of animals
In a blinded study where rats were treated for urinary infections results showed that rats treated with
homeopathic remedies had clear reduction of bacterial colonies. Results were at least as clear as for
treatment with antibiotics. Untreated rats had no changes in bacteria colonies, compared to a reduction
to 33 % of original bacteria levels in rats treated with antibiotics, and 22 % and 39 % in rats treated
with homeopathic remedies (Phosphorus and self-nosode).
Gonçalves et al. O uso da homeopatia no tratamento da infecção urinária em ratas. Anais do VIII
SINAPIH; 20-22 May, 2004: p.25-26.
A study of homeopathically protentised remedies showed a reduction in the need for repetition of
insemination and reduced semen loss in treatment of fertilisation of female pigs.
Riaucourt A. L´Exemple de la Filière Porcine. Annals of the “Entretiens Internationaux de Monaco
2002”, 5-6 October, 2002.
In a study of homeopathically potentised remedies the incidence of haematomas was reduced by 30 %
in turkeys during transportation. The study was randomised, placebo controlled and double blinded.
Filliat C. Particularité de l´utilisation de l´homéopathie en production avicole. Annals of the
“Entretiens Internationaux de Monaco 2002”, 5-6 October 2002.
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RESEARCH WEBSITE ADDRESSES
Pubmed (National Library of Medicine) www.ncbi.nlm.nih.gov/entrez/query.fcgi
British Medical Journal http://bmj.bmjjournals.com (search for 'homeopathy')
New Scientist www.newscientist.com (search for 'homeopathy')
Healthworld Online (Medline, Medical Research & Document Delivery)
www4.infotrieve.com/newmedline/summary.asp
Biomail www.biomail.org This site offers free regular updates by e-mail. Hosted by Medical Informatics
Department at State University of New York, Stony Brook University Hospital and Medical Centre.
An evidence-based resource about Complementary and Alternative Medicine www.cam.org.nz
Funded by the New Zealand Ministry of Health.
Annals of Internal Medicine www.annals.org/cgi/search?fulltext=homeopathy
University of York www.york.ac.uk/inst/crd/ehc73.pdf
Biomed Central (homeopathy review) www.biomedcentral.com/1472-6882/1/12
British Homeopathic Library www.hom-inform.org
The Research Council for Complementary Medicine www.rccm.org.uk
Groupe International de Recherche sur l'Infinitésimal www.giriweb.com
National Centre for Complementary and Alternative Medicine
www.campain.umm.edu/ris/risweb.isa (search for 'homeopathy')
National Centre for Homeopathy www.homeopathic.org/research.htm
Homeopathic Educational Services www.homeopathic.com/articles/research/index.php
Homeopathy (the journal) www.harcourt-international.com/journals/homp
Boiron www.boiron.com/en/htm/04-politique/clinique.htm
Official Indian research centre www.ccrhindia.org
Carstens stiftung (Germany)
www.carstens-stiftung.de
www.carstens-stiftung.de/eng/index.html (English pages)
ISI Web of Knowledge (resembles PubMed but includes more areas)
http://isi3.isiknowledge.com/portal.cgi
BMC Complementary and Alternative Medicine (free articles)
www.biomedcentral.com/1472-6882
NAFKAM, Tromsø (Norway) (research info will be included) http://uit.no/nafkam/omnafkam
Vifab (Denmark) www.vifab.dk
Townsend Letter for Doctors & Patients publishes a print alternative medicine magazine.
www.townsendletter.com
An Overview of Positive Homeopathy Research and Surveys, ENHR, March 2005 Page 12 of 12
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